Endocrine Abstracts

Aim: To measure Urocortin3 (Ucn3) blood levels in morbidly obese (MO) non diabetic patients before and after laparoscopic sleeve gastrectomy (LSG) for excess body weight reduction and explore its relationship with b-cell function. Ucn3 is involved in insulin secretion in the presence of nutrient excess, a key feature of obesity, and may be an integral part of the compensation of β-cells function.Methods: Nine MO patients who underwent LSG and 11 hea...

Corticotropin-releasing hormone (CRH) and Urocortin 2 (Urn2) are secreted locally in peripheral tissues and play a direct immunomodulatory role as endocrine or paracrine mediators of inflammation. Studies on CRH as well as Ucn2 and vascular endothelial cells suggest that CRH may play a pivotal role in the regulation of vascular endothelial function under normal and pathological conditions. The present study was undertaken to determine whether CRH and Urn2 affect the endothelia...

Introduction: GH deficiency in adulthood is associated with increased cardiovascular risk, which is attributed to unfavorable changes in body composition and in metabolic parameters.Aim: We evaluated haemodynamic, metabolic, inflammatory and coagulation indices that may contribute to the increased cardiovascular risk in GH deficient subjects.Methods: Twenty-four patients diagnosed with GH deficiency (13 male), with a mean (S...

Estrogens play an important role in male physiology. We investigated the possible association of four single nucleotide polymorphisms in estrogen receptor α (ER1) and Estrogen Receptor β (ER2) genes with circulating levels of sex steroids and Sex Hormone Binding Globulin (SHBG) in men.SHBG, total and calculated free testosterone (TT and cal FT), estradiol (E2) and free estradiol (FE2) were determined in a population based cohort of 170 apparent...

Introduction: Polycystic ovary syndrome (PCOS) is usually accompanied by abdominal obesity and insulin resistance which are related with low-grade chronic inflammation, as evidenced by elevation of multiple markers of inflammation, among which is oxidative stress. However, as far as oxidative stress presence, the existing data are limited. The purpose of this study was the investigation of several oxidative stress markers in women with PCOS without insulin resistance.<p cl...